An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children

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nihms-547014.pdf (1.09 MB)

Date

2014-01-03

Authors

Krafft, Cynthia E.
Pierce, Jordan E.
Schwarz, Nicolette F.
Chi, Lingxi
Weinberger, Abby L.
Schaeffer, David J.
Rodrigue, Amanda L.
Canchong, J.
Allison, Jerry David
Yanasak, Nathan Eugene

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Abstract

Children with low aerobic fitness have altered brain function compared to higher-fit children. This study examined the effect of an 8-month exercise intervention on resting state synchrony. Twenty-two sedentary, overweight (body mass index ≥85th percentile) children 8-11. years old were randomly assigned to one of two after-school programs: aerobic exercise (n= 13) or sedentary attention control (n= 9). Before and after the 8-month programs, all subjects participated in resting state functional magnetic resonance imaging scans. Independent components analysis identified several networks, with four chosen for between-group analysis: salience, default mode, cognitive control, and motor networks. The default mode, cognitive control, and motor networks showed more spatial refinement over time in the exercise group compared to controls. The motor network showed increased synchrony in the exercise group with the right medial frontal gyrus compared to controls. Exercise behavior may enhance brain development in children.

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Krafft, C. E., Pierce, J. E., Schwarz, N. F., Chi, L., Weinberger, A. L., Schaeffer, D. J., Rodrigue, A. L., Camchong, J., Allison, J. D., Yanasak, N. E., Liu, T., Davis, C. L., & McDowell, J. E. (2014). An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children. Neuroscience, 256, 445-455. https://doi.org/10.1016/j.neuroscience.2013.09.052

URI

http://hdl.handle.net/10675.2/624815

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Georgia Prevention Center: Faculty Research and Presentations