The Role of Uridine Adenosine Tetraphosphate in the Vascular System

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dc.contributor.authorMatsumoto, Takayuki
dc.contributor.authorTostes, Rita C.
dc.contributor.authorWebb, R. Clinton
dc.contributor.corporatenameDepartment of Physiology
dc.date.accessioned2012-10-26T20:30:41Z
dc.date.available2012-10-26T20:30:41Z
dc.date.issued2011-11-1en_US
dc.description.abstractThe endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.
dc.identifier.citationAdv Pharmacol Sci. 2011 Nov 1; 2011:435132en_US
dc.identifier.doi10.1155/2011/435132en_US
dc.identifier.issn1687-6342en_US
dc.identifier.pmcidPMC3206368en_US
dc.identifier.pmid22110488en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/765
dc.rightsCopyright © 2011 Takayuki Matsumoto et al.en_US
dc.subjectReview Articleen_US
dc.titleThe Role of Uridine Adenosine Tetraphosphate in the Vascular Systemen_US
dc.typeArticleen_US
html.description.abstractThe endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.
refterms.dateFOA2019-04-10T00:48:33Z

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