Next-Generation Sequencing (NGS) in COVID-19: A Tool for SARS-CoV-2 Diagnosis, Monitoring New Strains and Phylodynamic Modeling in Molecular Epidemiology

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dc.contributor.authorJohn, Goldin
dc.contributor.authorSahajpal, Nikhil Shri
dc.contributor.authorMondal, Ashis K.
dc.contributor.authorAnanth, Sudha
dc.contributor.authorWilliams, Colin
dc.contributor.authorChaubey, Alka
dc.contributor.authorRojiani, Amyn M.
dc.contributor.authorKolhe, Ravindra
dc.contributor.departmentDepartment of Pathologyen_US
dc.date.accessioned2022-03-09T18:43:01Z
dc.date.available2022-03-09T18:43:01Z
dc.date.issued2021-07-30
dc.description.abstractThis review discusses the current testing methodologies for COVID-19 diagnosis and explores next-generation sequencing (NGS) technology for the detection of SARS-CoV-2 and monitoring phylogenetic evolution in the current COVID-19 pandemic. The review addresses the development, fundamentals, assay quality control and bioinformatics processing of the NGS data. This article provides a comprehensive review of the obstacles and opportunities facing the application of NGS technologies for the diagnosis, surveillance, and study of SARS-CoV-2 and other infectious diseases. Further, we have contemplated the opportunities and challenges inherent in the adoption of NGS technology as a diagnostic test with real-world examples of its utility in the fight against COVID-19.en_US
dc.identifier.doi10.3390/cimb43020061
dc.identifier.eissn1467-3045
dc.identifier.journalCurrent Issues in Molecular Biologyen_US
dc.identifier.piicimb43020061
dc.identifier.urihttp://hdl.handle.net/10675.2/624246
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source.beginpage845
dc.source.endpage867
dc.source.issue2
dc.source.journaltitleCurrent Issues in Molecular Biology
dc.source.volume43
dc.subjectMicrobiology (medical)en_US
dc.subjectMolecular Biologyen_US
dc.subjectGeneral Medicineen_US
dc.subjectMicrobiologyen_US
dc.subjectnext-generation sequencing; COVID-19; challenges; diagnostic assayen_US
dc.titleNext-Generation Sequencing (NGS) in COVID-19: A Tool for SARS-CoV-2 Diagnosis, Monitoring New Strains and Phylodynamic Modeling in Molecular Epidemiologyen_US
dc.typeArticleen_US
refterms.dateFOA2022-03-09T18:43:01Z

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