Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

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dc.contributor.authorMi, Xiaofan
dc.contributor.authorHe, Hongzhi
dc.contributor.authorDeng, Yangxin
dc.contributor.authorLevin, Abert M
dc.contributor.authorShe, Jin-Xiong
dc.contributor.authorMi, Qing-Sheng
dc.contributor.authorZhou, Li
dc.contributor.corporatenameCenter for Biotechnology and Genomic Medicine
dc.date.accessioned2012-10-26T20:30:41Z
dc.date.available2012-10-26T20:30:41Z
dc.date.issued2011-10-20en_US
dc.description.abstractMicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.
dc.identifier.citationDiabetol Metab Syndr. 2011 Oct 20; 3:27en_US
dc.identifier.doi10.1186/1758-5996-3-27en_US
dc.identifier.issn1758-5996en_US
dc.identifier.pmcidPMC3215172en_US
dc.identifier.pmid22014115en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/767
dc.rightsCopyright ©2011 Mi et al; licensee BioMed Central Ltd.en_US
dc.subjectLetter to the Editoren_US
dc.titleLack of an association of miR-938 SNP in IDDM10 with human type 1 diabetesen_US
dc.typeArticleen_US
html.description.abstractMicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.
refterms.dateFOA2019-04-10T00:48:44Z

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