Design and Synthesis of Selective COX-2 Inhibitors as Potential Anti-inflammatory Agents

Abstract

Inflammation is a common immune response to harmful pathogens or damaged cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation as they inhibit the cyclooxygenase enzyme systems (COX). Selectivity for inhibition of the COX-2 pathway is an aim in the development of NSAIDs, as their adverse side effects are associated with the inhibition of the COX-1 pathway. We have designed and synthesized several hybrid conjugates of ibuprofen with various amino acid linkers showing promising anti-inflammatory properties and decreased gastric ulcer formation. The current developing new hybrid conjugates based on the rational drug design process. The details of the project will be discussed at the conference.