Analysis of Wilms Tumors Using SNP Mapping Array-Based Comparative Genomic Hybridization

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dc.contributor.authorHawthorn, Lesleyann
dc.contributor.authorCowell, John K.
dc.contributor.corporatenameGHSU Cancer Center
dc.date.accessioned2012-10-26T16:26:59Z
dc.date.available2012-10-26T16:26:59Z
dc.date.issued2011-04-22en_US
dc.description.abstractWilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 56 Wilms tumors using high resolution oligonucleotide arrays at a average resolution of â ¼12 Kb. Consistent deletions were seen on chromosomes 1p, 4q, 7p, 9q, 11p, 11q, 14q, 16q, and 21q. High frequency gains were seen for 1q and lower frequency gains were seen on 7q and chromosomes 8, 12 and 18. The high resolution provided by the SNP mapping arrays has defined minimal regions of deletion for many of these LOH events. Analysis of CNAs by tumor stage show relatively stable karyotypes in stage 1 tumors and more complex aCGH profiles in tumors from stages 3â 5.
dc.identifier.citationPLoS One. 2011 Apr 22; 6(4):e18941en_US
dc.identifier.doi10.1371/journal.pone.0018941en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmcidPMC3081321en_US
dc.identifier.pmid21544195en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/651
dc.rightsCowell, Hawthorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectBiologyen_US
dc.subjectComputational Biologyen_US
dc.subjectGeneticsen_US
dc.subjectHuman Geneticsen_US
dc.subjectPersonalized Medicineen_US
dc.subjectCancer Geneticsen_US
dc.subjectGenetics of Diseaseen_US
dc.subjectGenomicsen_US
dc.subjectGenome Expression Analysisen_US
dc.subjectMedicineen_US
dc.subjectOncologyen_US
dc.subjectCancers and Neoplasmsen_US
dc.subjectGastrointestinal Tumorsen_US
dc.titleAnalysis of Wilms Tumors Using SNP Mapping Array-Based Comparative Genomic Hybridizationen_US
dc.typeArticleen_US
html.description.abstractWilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 56 Wilms tumors using high resolution oligonucleotide arrays at a average resolution of â ¼12 Kb. Consistent deletions were seen on chromosomes 1p, 4q, 7p, 9q, 11p, 11q, 14q, 16q, and 21q. High frequency gains were seen for 1q and lower frequency gains were seen on 7q and chromosomes 8, 12 and 18. The high resolution provided by the SNP mapping arrays has defined minimal regions of deletion for many of these LOH events. Analysis of CNAs by tumor stage show relatively stable karyotypes in stage 1 tumors and more complex aCGH profiles in tumors from stages 3â 5.
refterms.dateFOA2019-04-10T00:24:43Z

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