Studies on NF-kB Activation During Reperfusion Injury Following Reversible Acute Ischemic Stroke

Abstract

Specific Aim # 1. To investigate whether reoxvsenation o f hypoxic cells results in the activation o f NF-kB in the HBMEC model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 2: To investigate whether reperfusion o f the ischemic brain tissue results in the activation o f NF-kB in the rat stroke model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 3: To test the efficacy o f antioxidants /NAC. PDTC) on the inhibition o f NF-kB activation following TNF-a-treatment or kwoxiaJreperfusion in the HBMEC model.