The examination of tianeptine as a possible treatment for traumatic brain injury.

Abstract

Tianeptine is an analgesic, antidepressant drug that has been previously studied for its benefits in improving recovery conditions in rodent models post injury or stress. In particular, it is of interest in the treatment of traumatic brain injury in humans, especially since there is currently no reliable treatment for human TBI patients. This project examined tianeptine’s efficacy in reducing ventricular enlargement in rodent models caused by TBI. Brain tissue samples were collected from the rodents and studied and the average areas of the lateral ventricle region were compared. The study found that, when administered to rodents with TBI, tianeptine treatments, while not significantly different, showed a strong trend for smaller ventricular areas when compared to saline vehicle treatments; overall, the ventricular area was smallest in rodents with sham surgeries and tianeptine treatments. In rodent models, tianeptine may be beneficial in reducing ventricular enlargement caused by TBI. It is worth exploring the anti-inflammatory benefits of tianeptine for its use as a treatment for TBI.