The Effects of Quinolinic Acid on Muscles and Bones

Abstract

Quinolinic acid (QA) is an NMDA-receptor agonist associated with several neurological illnesses, including Alzheimer's and Huntington's disease. QA is a metabolite of tryptophan known for its excitotoxic nature in high concentrations. However, in normal conditions it acts as a precursor in the manufacture of nicotinamide adenine dinucleotide (NAD+), a key molecule for energy synthesis. As people age, the quantity of tryptophan and its metabolites, such as QA, fluctuates. With age, QA levels rise, while tryptophan and NAD+ levels decline. QA's known association with energy production and beneficial properties is overlooked due to its toxic behavior. In this study, we hope to further examine QA through a different perspective by focusing on its potential healing properties rather than its harmful ones. We intend to investigate QA by identifying its effects on muscles and bone marrow stem cells. To decipher its effects, in vitro studies will be conducted. Through this process, we seek to learn if it has therapeutic qualities through cell proliferation and whether it stimulates stem cell differentiation. In the end, we believe that QA, a chemical with a negative connotation, will have notable healing effects on bones and muscles and will be able to provide possible linkage with healthy aging.