Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Vyavahare, Sagar; Kumar, Sandeep; Cantu, Nicholas; Kolhe, Ravindra; Bollag, Wendy B.; McGee-Lawrence, Meghan E.; Hill, William D.; Hamrick, Mark W.; Isales, Carlos M.; Fulzele, Sadanand

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

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tryptophan_kynurenine_pathway_in_covid19_dependent_musculoskeletal_pathology_a_mini_review.pdf (702.11 KB)

Date

2021-10-05

Authors

Vyavahare, Sagar

Kumar, Sandeep

Cantu, Nicholas

Kolhe, Ravindra

Bollag, Wendy B.

McGee-Lawrence, Meghan E.

Hill, William D.

Hamrick, Mark W.

Isales, Carlos M.

Fulzele, Sadanand

Publisher

Hindawi

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.